Rhode Island Multistate Pharmacy Jurisprudence (MPJE) Practice Exam

How often are media fills required to be performed with high-risk Compounded Sterile Preparations (CSPs)?

1. Every month

2. Every 3 months

3. Every 6 months

4. Every year

The correct answer is: Every 6 months

The correct answer regarding how often media fills are required to be performed with high-risk Compounded Sterile Preparations (CSPs) is every 6 months. This requirement is in place to ensure the sterility of high-risk CSPs, which present a higher potential risk for contamination during the compounding process due to the use of non-sterile ingredients or prolonged exposure to non-sterile conditions. Conducting media fills every 6 months allows for regular verification of aseptic technique and ensures that the compounding environment and practices are maintained at a standard that minimizes the risk of microbial contamination. This frequency is consistent with guidelines provided by organizations such as the United States Pharmacopeia (USP) and reflects the critical nature of maintaining sterility in high-risk preparations, where adherence to safety and quality measures is paramount. Maintaining this schedule ensures that compounding personnel are routinely assessed and that any potential issues can be addressed promptly, thereby supporting the safety of patients who rely on sterile preparations for their treatments.